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Oroxat (Roxadustat)
Therapeutic Class: Drugs for Hemolytic, Hypoplastic & Renal Anemia
Active Ingredient: Roxadustat
Form: Oral tablet
Storage: Store below 30°C in a dry place away from direct light. Keep out of reach of children.
Prescription Only: রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
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✅ Description:
Oroxat is indicated for the management of symptomatic anemia in adult patients with chronic kidney disease (CKD).
Oroxat is a first-in-class oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) that stimulates erythropoiesis (red blood cell formation). It works by increasing the body’s natural production of erythropoietin, enhancing iron availability, and minimizing the inflammation-induced suppression of hemoglobin synthesis. It effectively strengthens red blood cell production and iron metabolism by downregulating hepcidin levels.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
- Hypertension
- Vascular access thrombosis
- Diarrhea
- Peripheral edema
- Hyperkalemia
- Nausea
✔️ Pharmacology
Roxadustat is an orally active HIF-PH inhibitor. By blocking HIF-PH enzymes that normally degrade HIF proteins under normal oxygen levels, it boosts HIF activity. This leads to:
Elevated endogenous erythropoietin (EPO) production
Decreased hepcidin levels
Improved iron absorption and mobilization
Enhanced hemoglobin (Hb) levels
It induces a coordinated erythropoietic response while maintaining EPO levels within the physiological range, even in inflamed states or without IV iron.
Roxadustat has also been shown to reduce cholesterol levels, regardless of statin usage.
✔️ Dosage & Administration
Frequency: Three times weekly (non-consecutive days)
With or without food
For patients not previously on erythropoiesis-stimulating agents (ESAs):
Start with 50 mg three times weekly.
Weight-based dosing:
- <100 kg: 70 mg
- ≥100 kg: 100 mg
For patients switching from ESAs:
Start with 70 mg or 100 mg three times weekly depending on previous treatment and patient condition.
Dose Adjustment:
Modify doses based on hemoglobin response and tolerability using the sequence:
20 mg → 40 mg → 50 mg → 70 mg → 100 mg → 150 mg → 200 mg → 250 mg → 300 mg → 400 mg (400 mg reserved for dialysis-dependent CKD).
Maintain each dose level for at least 4 weeks.
If Hb rises >2.0 g/dL within 4 weeks, reduce the dose or temporarily stop.
✔️ Interactions
Avoid co-administration or adjust timing/dosing with:
- Phosphate binders/multivalent cation products (except lanthanum carbonate):
↓ Roxadustat absorption. Take Oroxat at least 1 hour later.
Gemfibrozil, Probenecid:
↑ Roxadustat exposure. Monitor Hb and adjust dose accordingly.
Statins (simvastatin, rosuvastatin, atorvastatin):
↑ Statin levels. Monitor and adjust dose as needed.
✔️ Missed Dose:
≥24 hours before next dose: Take immediately.
<24 hours before next dose: Skip missed dose. Do not double-dose.
- Pediatrics: Not recommended
- Severe hepatic impairment: Use is not advised
✔️ Use Oroxat cautiously in:
Patients with a history of thrombotic vascular events (TVEs), obesity, or prior TVEs
- Those with a history of seizures
- Patients with active infections or liver dysfunction
- Pregnant women – not recommended to initiate treatment
✔️ Pregnancy & Lactation
- Contraindicated in pregnant women
- Not to be used during breastfeeding
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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